The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Detects a band of approximately 37 kDa (predicted molecular weight: 37 kDa).
RelevanceB4GALT7 belongs to the glycosyltransferase 7 family. It is required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts.
Defects in B4GALT7 are the cause of progeroid Ehlers-Danlos syndrome (EDS). EDSP is a variant form of Ehlers-Danlos syndrome characterized by progeroid facies, mild mental retardation, short stature, skin hyperextensibility, moderate skin fragility, joint hypermobility principally in digits.
Cellular localizationGolgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Note: Cis cisternae of Golgi stack