Overview

  • Product name
    Anti-B7H4 antibody [H74]
    See all B7H4 primary antibodies
  • Description
    Mouse monoclonal [H74] to B7H4
  • Tested applications
    Suitable for: IHC-P, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human B7H4

  • Positive control
    • Human B7H4 transfected 293T cells, Human Pancreas and Human Spleen tissues
  • General notes

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause.

Properties

Applications

Our Abpromise guarantee covers the use of ab110160 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 20 µg/ml.
Flow Cyt Use 0.25µg for 105-8 cells. in 100 ul



ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • Function
    Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
  • Tissue specificity
    Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
  • Sequence similarities
    Belongs to the immunoglobulin superfamily. BTN/MOG family.
    Contains 2 Ig-like V-type (immunoglobulin-like) domains.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Cell membrane. Expressed at the cell surface. A soluble form has also been detected.
  • Information by UniProt
  • Database links
  • Alternative names
    • B7 family member, H4 antibody
    • B7 H4 antibody
    • B7 homolog 4 antibody
    • B7 superfamily member 1 antibody
    • B7 superfamily, member 1 antibody
    • B7-H4 antibody
    • B7h.5 antibody
    • B7h4 antibody
    • B7S1 antibody
    • B7x antibody
    • BC032925 antibody
    • Immune costimulatory protein B7-H4 antibody
    • Immune costimulatory protein B7H4 antibody
    • MGC41287 antibody
    • PRO1291 antibody
    • Protein B7S1 antibody
    • RP11 229A19.4 antibody
    • T cell costimulatory molecule B7x antibody
    • T-cell costimulatory molecule B7x antibody
    • V set domain-containing T cell activation inhibitor 1 antibody
    • V-set domain-containing T-cell activation inhibitor 1 antibody
    • VCTN1 antibody
    • Vtcn1 antibody
    • VTCN1_HUMAN antibody
    see all

Images

  • Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE) using ab110160 at a concentration of 20 µg/ml.
  • Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) using ab110160 at a concentration of 20 µg/ml.
  • Staining of non-transfected 293T cells with 0.125 ug of Purified Mouse IgG1, K isotype control (open histogram) or 0.125 ug of ab110160 (colored histogram) followed by Biotin Anti-Mouse IgG and SAv-PE. Total cells were used for analysis.
  • Staining of Human B7H4 transfected 293T cells with 0.125 ug of Purified Mouse IgG1, K isotype control (open histogram) or 0.125 ug of ab110160 (colored histogram) followed by Biotin Anti-Mouse IgG and SAv-PE. Total cells were used for analysis.

References

ab110160 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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