Overview

  • Product name
  • Description
    Rabbit polyclonal to Baboon
  • Specificity
    The antibody is unique to Baboon protein.
  • Tested applications
    Suitable for: IP, WBmore details
  • Species reactivity
    Reacts with: Drosophila melanogaster
  • Immunogen

    Synthetic peptide:

    QPDPSIEEMKKVVCIEKCRPN

    , corresponding to amino acids 552 to 572 of Baboon. The was generated against a peptide sequence near the C terminal end of the protein. The peptides was amidated for conjugation.

  • Positive control
    • Drosophila melanogaster extracts.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    Purified against immobilized antigen based affinity chromatography which yielded epitope specific antibodies.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab14682 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP
WB
  • Application notes
    IP: 1/200.
    WB: 1/500.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      Transmembrane receptor Patched regulates several developmental processes in both invertebrates and vertebrates. In higher vertebrates the patched (Ptc) also acts as a tumor suppressor. The patched receptor signaling involves negatively regulating a GPCR, smoothened. The binding Hedgehog ligand to Ptc removes the negative interaction of Ptc, and allows the signaling by smoothened. It has been shown that during head morphogenesis in D. melanogaster, Ptc positively interacts with smoothened, which leads to stimulation of Activin type 1 receptor Baboon, and activation of cell proliferation in the eye antennal disc. The expression of activated Baboon in the Ptc domain in Ptc mutant background completely abolish the head developmental defects.
    • Database links
      • Alternative names
        • ATR1 antibody
        • AtrI antibody
        • Bab antibody
        • Babo antibody
        • G protein coupled receptor kinase 3 antibody
        • STKE antibody
        see all

      References

      This product has been referenced in:
      • Lai YW  et al. Drosophila microRNA-34 Impairs Axon Pruning of Mushroom Body ? Neurons by Downregulating the Expression of Ecdysone Receptor. Sci Rep 6:39141 (2016). Read more (PubMed: 28008974) »

      See 1 Publication for this product

      Customer reviews and Q&As

      Application
      IHC - Wholemount
      Sample
      Fruit fly (Drosophila melanogaster) Tissue (Brain)
      Specification
      Brain
      Username

      Abcam user community

      Verified customer

      Submitted Aug 20 2015

      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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