Overview

  • Product nameAnti-BACE1 antibody
    See all BACE1 primary antibodies
  • Description
    Rabbit polyclonal to BACE1
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S498 of human BACE1.

  • Positive control
    • Mouse cerebellum tissue lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab76019 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesELISA: 1/1000.
    WB: 1/50 - 1/100. Detects bands of approximately 28, 34, 56 and 60 kDa (predicted molecular weight: 56 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionResponsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
    • Tissue specificityExpressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
    • Sequence similaritiesBelongs to the peptidase A1 family.
    • DomainThe transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP.
    • Post-translational
      modifications
      Glycosylated.
    • Cellular localizationMembrane. Golgi apparatus > trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.
    • Information by UniProt
    • Database links
    • Alternative names
      • APP beta secretase antibody
      • Asp 2 antibody
      • ASP2 antibody
      • Aspartyl protease 2 antibody
      • BACE 1 antibody
      • BACE antibody
      • BACE1 antibody
      • BACE1_HUMAN antibody
      • Beta secretase 1 antibody
      • Beta secretase antibody
      • Beta site amyloid beta A4 precursor protein cleaving enzyme antibody
      • Beta site amyloid precursor protein cleaving enzyme 1 antibody
      • Beta site amyloid precursor protein cleaving enzyme antibody
      • Beta site APP cleaving enzyme 1 antibody
      • Beta site APP cleaving enzyme antibody
      • Beta-secretase 1 antibody
      • Beta-site amyloid precursor protein cleaving enzyme 1 antibody
      • Beta-site APP cleaving enzyme 1 antibody
      • FLJ90568 antibody
      • HSPC104 antibody
      • Memapsin 2 antibody
      • Memapsin-2 antibody
      • Memapsin2 antibody
      • Membrane associated aspartic protease 2 antibody
      • Membrane-associated aspartic protease 2 antibody
      • Transmembrane aspartic proteinase Asp2 antibody
      see all

    Anti-BACE1 antibody images

    • Anti-BACE1 antibody (ab76019) at 1/50 dilution + Mouse cerebellum tissue lysates at 35 µg

      Predicted band size : 56 kDa
      Observed band size : 56 kDa
      Additional bands at : 28 kDa,34 kDa,60 kDa. We are unsure as to the identity of these extra bands.

    References for Anti-BACE1 antibody (ab76019)

    ab76019 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab76019.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"