• Product name
  • Description
    Rabbit polyclonal to BACE2
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide:


    , corresponding to amino acids 44-59 of Human BACE 2.

  • Positive control
    • Human heart tissue lysate.
  • General notes
    Beta-site APP Cleaving Enzyme



Our Abpromise guarantee covers the use of ab8025 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Can be blocked with BACE2 peptide (ab8392).


  • Function
    Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
  • Tissue specificity
    Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
  • Sequence similarities
    Belongs to the peptidase A1 family.
  • Post-translational
    Undergoes autoproteolytic cleavage.
  • Cellular localization
    Membrane. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.
  • Information by UniProt
  • Database links
  • Alternative names
    • ALP 56 antibody
    • ALP56 antibody
    • Asp 1 antibody
    • ASP1 antibody
    • ASP21 antibody
    • Aspartic Like Protease 56kDa antibody
    • Aspartic-like protease 56 kDa antibody
    • Aspartyl protease 1 antibody
    • BACE 2 antibody
    • Bace2 antibody
    • BACE2_HUMAN antibody
    • Beta Secretase 2 antibody
    • Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2 antibody
    • Beta-secretase 2 antibody
    • Beta-site amyloid precursor protein cleaving enzyme 2 antibody
    • Beta-site APP cleaving enzyme 2 antibody
    • Down region aspartic protease antibody
    • Downs Syndrome Region Aspartic Protease antibody
    • DRAP antibody
    • Memapsin 1 antibody
    • Memapsin-1 antibody
    • Membrane associated aspartic protease 1 antibody
    • Membrane-associated aspartic protease 1 antibody
    • Theta-secretase antibody
    see all

Anti-BACE2 antibody images

  • Western blot analysis of BACE2 in human (A) and mouse (B) heart tissue lysates with Ab8025 at 1 µg/ml.

References for Anti-BACE2 antibody (ab8025)

This product has been referenced in:

See 1 Publication for this product

Product Wall

Thank you for contacting us and letting us know about this situation. Thank you also for your patience,as I have been in touch with the labs that produce these BACE1 and BACE2 antibodies. The specificity of the BACE1 antibody ab62034 was determined by ...

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Thank you for your enquiry. The sequence does not exist as an exact match of the 16 residues, but at least four mouse proteins have enough homology with the sequence to indicate that cross-reactivity is possible, having a band of the same size. ...

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