Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2
Beta-site amyloid precursor protein cleaving enzyme 2
Beta-site APP cleaving enzyme 2
Down region aspartic protease
Downs Syndrome Region Aspartic Protease
Membrane associated aspartic protease 1
Membrane-associated aspartic protease 1
FunctionResponsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
Tissue specificityBrain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
Sequence similaritiesBelongs to the peptidase A1 family.