Overview

  • Product name
  • Description
    Rabbit polyclonal to BAF53b
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 50-80 of Human BAF53b (NP_057272.1).

  • Positive control
    • HepG2 cell line lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab103771 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 47 kDa.

Target

  • Function
    Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth.
  • Sequence similarities
    Belongs to the actin family.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 53 kDa BRG1 associated factor B antibody
    • 53 kDa BRG1-associated factor B antibody
    • ACL 6B antibody
    • ACL6B antibody
    • ACL6B_HUMAN antibody
    • Actin like 6 antibody
    • Actin like protein 6B antibody
    • Actin like protein6B antibody
    • Actin related protein antibody
    • Actin related protein Baf53b antibody
    • actin-like 6B antibody
    • Actin-like protein 6B antibody
    • Actin-related protein Baf53b antibody
    • Actl 6 antibody
    • ACTL 6B antibody
    • Actl6 antibody
    • ACTL6 B antibody
    • Actl6b antibody
    • Arp Na antibody
    • ArpN a antibody
    • ArpN alpha antibody
    • ArpNa antibody
    • ArpNalpha antibody
    • Baf 53b antibody
    • BAF53B antibody
    • BRG1-associated factor 53B antibody
    see all

Images

  • Anti-BAF53b antibody (ab103771) at 1/100 dilution + HepG2 cell line lysates at 35 µg

    Predicted band size : 47 kDa

References

This product has been referenced in:
  • You JS  et al. SNF5 is an essential executor of epigenetic regulation during differentiation. PLoS Genet 9:e1003459 (2013). WB ; Human . Read more (PubMed: 23637628) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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