Our Abpromise guarantee covers the use of ab58217 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInvolved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.
    • Sequence similaritiesContains 1 HMG box DNA-binding domain.
    • DomainThe HMG domain is essential for CD4 silencing and CD8 activation; mutation of this domain blocks thymus development.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • BAF57 antibody
      • BRG1 associated factor 57 antibody
      • BRG1-associated factor 57 antibody
      • Chromatin remodeling complex BRG1 associated factor 57 antibody
      • FLJ35648 antibody
      • SMARCE 1 antibody
      • SMARCE1 antibody
      • SMCE1_HUMAN antibody
      • SWI/SNF related matrix associated actin dependent regulator of chromatin e1 antibody
      • SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily e member 1 antibody
      • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 antibody
      see all

    Anti-BAF57/SMARCE1 antibody images

    • Western blot against tagged recombinant protein immunogen using ab58217 BAF57/SMARCE1 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa

    References for Anti-BAF57/SMARCE1 antibody (ab58217)

    ab58217 has not yet been referenced specifically in any publications.

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