Biotin Anti-BAFF-R antibody [11C1] (ab16582)
Key features and details
- Biotin Mouse monoclonal [11C1] to BAFF-R
- Suitable for: IHC-Fr, IHC (PFA fixed), Flow Cyt
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG1
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Biotin Anti-BAFF-R antibody [11C1]
See all BAFF-R primary antibodies -
Description
Biotin Mouse monoclonal [11C1] to BAFF-R -
Host species
Mouse -
Conjugation
Biotin -
Tested applications
Suitable for: IHC-Fr, IHC (PFA fixed), Flow Cytmore details -
Species reactivity
Reacts with: Human -
Immunogen
Tissue, cells or virus corresponding to Human BAFF-R. Transfected mouse B cell lymphoma L1.2 cells.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
11C1 -
Myeloma
Sp2/0 -
Isotype
IgG1 -
Research areas
Associated products
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab16582 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-Fr | ||
IHC (PFA fixed) | ||
Flow Cyt |
Notes |
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IHC-P: Use at an assay dependent dilution. Antigen retrieval with EDTA based solution (pH9.0) and heat.
IHC-Fr: Use at an assay dependent dilution.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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Function
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. -
Tissue specificity
Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. -
Involvement in disease
Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. -
Sequence similarities
Contains 1 TNFR-Cys repeat. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 115650 Human
- Omim: 606269 Human
- SwissProt: Q96RJ3 Human
- Unigene: 344088 Human
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Alternative names
- B cell activating factor receptor antibody
- B-cell-activating factor receptor antibody
- BAFF R antibody
see all
Protocols
Datasheets and documents
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Datasheet download
References (2)
ab16582 has been referenced in 2 publications.
- Xu H et al. Abnormally high expression of BAFF on T lymphocytes from lung cancer-associated pleural effusions and its potent anti-tumor effect. Acta Biochim Biophys Sin (Shanghai) 39:964-73 (2007). Flow Cyt ; Human . PubMed: 18064389
- Ng LG et al. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol 173:807-17 (2004). PubMed: 15240667