Overview

  • Product nameBafilomycin A1
  • Description
    Highly potent, selective (V)-ATPase inhibitor
  • Purity> 98%

Properties

  • Chemical name(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
  • Molecular weight622.84
  • Chemical structureChemical Structure
  • Molecular formulaC35H58O9
  • CAS Number88899-55-2
  • Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESO[C@@]1(C[C@@H](O)[C@H](C)[C@H](O1)C(C)C)[C@@H](C)[C@H](O)[C@H](C)C2OC(=O)C(OC)=CC=C(C)[C@@H](C)[C@@H](O)[C@@H](C)CC(C)=CC=C[C@@H]2OC
  • Source

    Streptomyces griseus

  • Research areas

    References for Bafilomycin A1 (ab120497)

    This product has been referenced in:
    • van Schalkwyk DA  et al. Inhibition of Plasmodium falciparum pH regulation by small molecule indole derivatives results in rapid parasite death. Biochem Pharmacol 79:1291-9 (2010). Read more (PubMed: 20067768) »
    • Shacka JJ  et al. Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons. Mol Pharmacol 69:1125-36 (2006). Read more (PubMed: 16391239) »
    • Niikura K Vacuolar ATPase as a drug discovery target. Drug News Perspect 19:139-44 (2006). Read more (PubMed: 16804565) »

    See all 5 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"