Overview

  • Product nameAnti-Bag3 antibody
    See all Bag3 primary antibodies
  • Description
    Goat polyclonal to Bag3
  • Tested applicationsSuitable for: WB, IHC-P, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    C-SSMTDTPGNPAAP

    , corresponding to C terminal amino acids 563-575 of Human Bag3.

  • Positive control
    • Human Heart, Human Skeletal Muscle and Human Placenta tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab112016 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 mg/ml. Predicted molecular weight: 62 kDa.
IHC-P Use a concentration of 3.75 µg/ml.
ELISA 1/8000.

Target

  • FunctionInhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.
  • Involvement in diseaseDefects in BAG3 are the cause of myopathy myofibrillar BAG3-related (MFM-BAG3) [MIM:612954]. A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material.
  • Sequence similaritiesContains 1 BAG domain.
    Contains 2 WW domains.
  • Information by UniProt
  • Database links
  • Alternative names
    • BAG 3 antibody
    • BAG family molecular chaperone regulator 3 antibody
    • BAG-3 antibody
    • Bag3 antibody
    • BAG3_HUMAN antibody
    • Bcl 2 binding protein antibody
    • Bcl-2-associated athanogene 3 antibody
    • Bcl-2-binding protein Bis antibody
    • BCL2 associated athanogene 3 antibody
    • BCL2 binding athanogene 3 antibody
    • BIS antibody
    • CAIR 1 antibody
    • Docking protein CAIR 1 antibody
    • Docking protein CAIR-1 antibody
    • MFM6 antibody
    see all

Anti-Bag3 antibody images

  • Immunohistochemical analysis of Bag3 expression in formalin-fixed, paraffin-embedded Human heart tissue using ab112016 at 3.75 µg/ml.
  • Immunohistochemical analysis of Bag3 expression in formalin-fixed, paraffin-embedded Human skeletal muscle tissue using ab112016 at 3.75 µg/ml.
  • Immunohistochemical analysis of Bag3 expression in formalin-fixed, paraffin-embedded Human placenta tissue using ab112016 at 3.75 µg/ml.

References for Anti-Bag3 antibody (ab112016)

ab112016 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"