Recombinant full length protein, corresponding to amino acids 1-448 of Human Bag5
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 51 kDa.
Use at an assay dependent concentration. PubMed: 24475098
Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
Contains 5 BAG domains.
The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.
Qin LX et al. BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage. Oxid Med Cell Longev2017:5094934 (2017).
Read more (PubMed: 28348719) »
Wang X et al. BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. PLoS One9:e86276 (2014).
Read more (PubMed: 24475098) »