FunctionIn the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.
Tissue specificityExpressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
Sequence similaritiesBelongs to the Bcl-2 family.
DomainIntact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Anti-Bak antibody [AT8B4] (ab104124) at 1/500 dilution + Mouse lung lyasate at 35 µg
Secondary Goat anti-mouse HRP conjugate Developed using the ECL technique
Predicted band size : 23 kDa
Immunocytochemistry/ Immunofluorescence - Bak antibody [AT8B4] (ab104124)
Immunofluorescence staining of Bak in HeLa cells using Hoechst 3342 (Blue) for nucleus staining and ab104124 antibody (1/500) with Texas Red (Red).
References for Anti-Bak antibody [AT8B4] (ab104124)
This product has been referenced in:
Singh A et al. Podophyllotoxin and Rutin Modulates Ionizing Radiation-Induced Oxidative Stress and Apoptotic Cell Death in Mice Bone Marrow and Spleen. Front Immunol8:183 (2017).
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