BAM (8-22) (Bovine Adrenal Medulla 8-22) (ab120178)

Overview

  • Product name
    BAM (8-22) (Bovine Adrenal Medulla 8-22)
  • Description
    SNSR agonist
  • Alternative names
    • Bovine Adrenal Medulla 8-22
  • Biological description
    Endogenous peptide fragment that is a selective agonist for the sensory neuron specific receptor (EC50 values are 28 and 14 nM for SNSR3 and SNSR4, respectively). Inhibits development of morphine tolerance in rats, and exerts spinal analgesic effects by an interaction with NMDA receptors.
  • Purity
    > 95%

Properties

References

This product has been referenced in:
  • Chen T  et al. Modulation of NMDA receptors by intrathecal administration of the sensory neuron-specific receptor agonist BAM8-22. Neuropharmacology 54:796-803 (2008). Read more (PubMed: 18249418) »
  • Cai Q  et al. Sensory neuron-specific receptor agonist BAM8-22 inhibits the development and expression of tolerance to morphine in rats. Behav Brain Res 178:154-9 (2007). Read more (PubMed: 17227682) »
  • Lembo PM  et al. Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs. Nat Neurosci 5:201-9 (2002). Read more (PubMed: 11850634) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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