Overview

  • Product name
    BAM7
  • Description
    Selective BAX activator
  • Alternative names
    • BAM 7
    • BAX activator molecule 7
  • Biological description

    Selective BAX activator (EC50 = 3.3 μM). Directly binds at the BH3-binding site; selective for BAX over other antiapoptotic and proapoptotic proteins. Triggers in vitro BAX oligomerization, BAX-mediated pore formation and BAX-dependent cell death. Selectively induces BAX-mediated apoptosis by triggering the hallmark features of intracellular BAX activation. Only kills the cell line that contains BAX, eliciting the biochemical and morphologic features of BAX-mediated apoptosis.

  • Purity
    > 98%

Properties

  • Chemical name
    3-Methyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(2-ethoxyphenyl)hydrazone]
  • Molecular weight
    405.47
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C21H19N5O2S
  • CAS Number
    331244-89-4
  • PubChem identifier
    5754137
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Solubility overview
    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CCOC1=CC=CC=C1N/N=C/2\C(=NN(C2=O)C3=NC(=CS3)C4=CC=CC=C4)C
  • Source

    Synthetic

References

This product has been referenced in:
  • Wu CR  et al. Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson's disease: involvement of antioxidative enzymes induction. Chem Biol Interact 225:40-6 (2015). Read more (PubMed: 25446857) »
  • Gavathiotis E  et al. Direct and selective small-molecule activation of proapoptotic BAX. Nat Chem Biol 8:639-45 (2012). Read more (PubMed: 22634637) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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