Overview

  • Product nameBAN ORL 24
  • Description
    Potent, selective ORL1 non-peptide agonist
  • Biological descriptionPotent, selective, competitive ORL1 non-peptide agonist. Displays 1000-fold selectivity over classical opioid receptors. IC50 values for receptor subtypes are 0.27 (ORL1), 6700 (μ), 2500 (κ) and >10000 (δ) nM. Systemic administration alleviates experimental Parkinson's in rats.
  • Purity> 95%

Properties

  • Chemical name(2R)-1-(Phenylmethyl)-N-(3-spiro[isobenzofuran-1(3H)-4'-piperidin]-1-ylpropyl)-2-pyrrolidinecarboxamide dihydrochloride
  • Molecular weight506.51
  • Chemical structureChemical Structure
  • Molecular formulaC27H35N3O2.2HCl
  • CAS Number1401463-54-4
  • Storage instructionsStore at -20°C. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store under Desiccating conditions.
  • Solubility overviewSoluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

    References for BAN ORL 24 (ab120671)

    This product has been referenced in:
    • Volta M  et al. Dopamine-nociceptin/orphanin FQ interactions in the substantia nigra reticulata of hemiparkinsonian rats: involvement of D2/D3 receptors and impact on nigro-thalamic neurons and motor activity. Exp Neurol 228:126-37 (2011). Read more (PubMed: 21215744) »

    See all 3 Publications for this product

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