Biological descriptionPotent, selective, competitive ORL1 non-peptide agonist. Displays 1000-fold selectivity over classical opioid receptors. IC50 values for receptor subtypes are 0.27 (ORL1), 6700 (μ), 2500 (κ) and >10000 (δ) nM. Systemic administration alleviates experimental Parkinson's in rats.
Chemical name(2R)-1-(Phenylmethyl)-N-(3-spiro[isobenzofuran-1(3H)-4'-piperidin]-1-ylpropyl)-2-pyrrolidinecarboxamide dihydrochloride
Storage instructionsStore at -20°C. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store under Desiccating conditions.
Solubility overviewSoluble in water to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Volta M et al. Dopamine-nociceptin/orphanin FQ interactions in the substantia nigra reticulata of hemiparkinsonian rats: involvement of D2/D3 receptors and impact on nigro-thalamic neurons and motor activity. Exp Neurol228:126-37 (2011).
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