Overview

  • Product nameAnti-BAPX1 antibody
    See all BAPX1 primary antibodies
  • Description
    Rabbit polyclonal to BAPX1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rabbit, Chicken, Guinea pig, Cow, Dog
  • Immunogen

    A synthetic peptide corresponding to a region within the N terminal amino acids 2-51(

    AVRGANTLTSFSIQAILNKKEERGGLAAPEGRPAPGGTAASVAAAPAVCC

    ) of Human BAPX1, NP_001180.

  • Positive control
    • Jurkat cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab85429 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 35 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionTranscriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus.
  • Tissue specificityExpressed at highest levels in cartilage, bone (osteosarcoma) and gut (small intestine and colon), whereas moderate expression is seen in trachea and brain. Expressed in visceral mesoderm and embryonic skeleton.
  • Involvement in diseaseDefects in NKX3-2 are the cause of spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD) [MIM:613330]. It is a skeletal dysplasia characterized by disproportionate short stature with a short and stiff neck and trunk, relatively long limbs that may show flexion contractures of the distal joints, delayed and impaired ossification of the vertebral bodies, the presence of large epiphysea ossification centers and wide growth plates in the long tubular bones and numerous pseudoepiphyses of the short tubular bones in hands and feet.
  • Sequence similaritiesBelongs to the NK-3 homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Bagpipe homeobox 1 antibody
    • Bagpipe homeobox homolog 1 antibody
    • Bagpipe homeobox protein homolog 1 antibody
    • Bagpipe homeobox, Drosophila, homolog of, 1 antibody
    • BAPX 1 antibody
    • Homeobox protein NK-3 homolog B antibody
    • Homeobox protein Nkx 3.2 antibody
    • Homeobox protein Nkx-3.2 antibody
    • MGC138171 antibody
    • NK3 homeobox 2 antibody
    • NKX3 2 antibody
    • NKX3-2 antibody
    • NKX3.2 antibody
    • NKX3.2, mouse, homolog of antibody
    • NKX32_HUMAN antibody
    • NKX3B antibody
    • OTTHUMP00000115816 antibody
    • SMMD antibody
    see all

Anti-BAPX1 antibody images

  • Anti-BAPX1 antibody (ab85429) at 1 µg/ml (in 5% skim milk / PBS buffer) + Jurkat cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 35 kDa
    Observed band size : 35 kDa
    Additional bands at : 60 kDa,65 kDa. We are unsure as to the identity of these extra bands.

References for Anti-BAPX1 antibody (ab85429)

ab85429 has not yet been referenced specifically in any publications.

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