Overview

  • Product nameAnti-BCCIP antibody
    See all BCCIP primary antibodies
  • Description
    Rabbit polyclonal to BCCIP
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Lizard, Gorilla
  • Immunogen

    Synthetic peptide corresponding to a region within amino acids 300-350 of Human BCCIP (NP_510868.1).

  • Positive control
    • Human Breast Carcinoma, Colon Carcinoma, Ovarian Carcinoma and Testicular Seminoma tissues

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab113288 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

Target

  • FunctionMay promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
  • Tissue specificityExpressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen.
  • Sequence similaritiesBelongs to the BCP1 family.
  • Developmental stageIsoform 1 is expressed throughout the cell cycle. Isoform 2 is expressed following mitosis and peaks in the G1/S phase of the cell cycle.
  • Cellular localizationNucleus. Colocalizes with BRCA2 in discrete nuclear foci.
  • Information by UniProt
  • Database links
  • Alternative names
    • bccip antibody
    • BCCIP_HUMAN antibody
    • BCCIPalpha antibody
    • BCCIPbeta antibody
    • BRCA2 and CDKN1A interacting protein antibody
    • BRCA2 and CDKN1A-interacting protein antibody
    • BRCA2 and Cip1/p21 interacting protein antibody
    • Cdk inhibitor p21 binding protein antibody
    • P21 and CDK associated protein 1 antibody
    • P21- and CDK-associated protein 1 antibody
    • Protein TOK-1 antibody
    • Protein TOK1 antibody
    • TOK 1 antibody
    • TOK 1alpha antibody
    • TOK 1beta antibody
    • TOK1 antibody
    see all

Anti-BCCIP antibody images

  • ab113288, at 1/250 dilution, staining BCCIP in formalin-fixed, paraffin-embedded Human Colon Carcinoma by Immunohistochemistry with DAB staining.
  • ab113288, at 1/250 dilution, staining BCCIP in formalin-fixed, paraffin-embedded Human testicular seminoma by Immunohistochemistry with DAB staining.
  • ab113288, at 1/100 dilution, staining BCCIP in formalin-fixed, paraffin-embedded Human breast carcinoma by Immunohistochemistry. Detection: Red-fluorescent Goat anti-Rabbit IgG-heavy and light chain cross-adsorbed Antibody DyLight® 594 Conjugated used at a dilution of 1/100.

References for Anti-BCCIP antibody (ab113288)

ab113288 has not yet been referenced specifically in any publications.

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