Overview

  • Product name
  • Description
    Rabbit polyclonal to BCCIP
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within amino acids 181-243 of Human BCCIP (Q9P287)

  • Positive control
    • A431, Hela, 293T or HepG2 cell lines.

Properties

Applications

Our Abpromise guarantee covers the use of ab97577 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 36 kDa.
ICC/IF 1/200.

Target

  • Function
    May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
  • Tissue specificity
    Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen.
  • Sequence similarities
    Belongs to the BCP1 family.
  • Developmental stage
    Isoform 1 is expressed throughout the cell cycle. Isoform 2 is expressed following mitosis and peaks in the G1/S phase of the cell cycle.
  • Cellular localization
    Nucleus. Colocalizes with BRCA2 in discrete nuclear foci.
  • Information by UniProt
  • Database links
  • Alternative names
    • bccip antibody
    • BCCIP_HUMAN antibody
    • BCCIPalpha antibody
    • BCCIPbeta antibody
    • BRCA2 and CDKN1A interacting protein antibody
    • BRCA2 and CDKN1A-interacting protein antibody
    • BRCA2 and Cip1/p21 interacting protein antibody
    • Cdk inhibitor p21 binding protein antibody
    • P21 and CDK associated protein 1 antibody
    • P21- and CDK-associated protein 1 antibody
    • Protein TOK-1 antibody
    • Protein TOK1 antibody
    • TOK 1 antibody
    • TOK 1alpha antibody
    • TOK 1beta antibody
    • TOK1 antibody
    see all

Images

  • All lanes : Anti-BCCIP antibody (ab97577) at 1/1000 dilution

    Lane 1 : A431 whole cell lysate
    Lane 2 : HeLa whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 36 kDa
  • Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells, using ab97577 at 1/200 dilution. Bottom picture shows stain merged with DNA probe.

References

ab97577 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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