The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 26 kDa (predicted molecular weight: 25 kDa).Can be blocked with Human Bcl 7A peptide (ab22792).
Involvement in diseaseNote=Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions.
Sequence similaritiesBelongs to the BCL7 family.
Post-translational modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.