Overview

  • Product nameAnti-Bcl x antibody
    See all Bcl x primary antibodies
  • Description
    Rabbit polyclonal to Bcl x
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Hamster, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide:

    ETPSAINGNPSWHLADSPAVN

    , corresponding to internal sequence amino acids 46-66 of Human Bcl x.

  • Positive control
    • Hodgkin's lymphoma

Properties

Applications

Our Abpromise guarantee covers the use of ab93023 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/50 - 1/100 in an ABC method. An incubation period of 30 minutes at room temperature is recommended. Formalin fixed, paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6 prior to immunostaining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceBcl x is a member of the Bcl 2 family of proteins, which function as regulators of apoptosis. It may provide neuroprotection against ischemic brian injury. Bcl x has two isoforms, Bcl xl (long) a 241 amino acid protein and Bcl xs (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the Bcl2 family. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.
    • Cellular localizationMitochondrion membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Note: Mitochondrial membranes and perinuclear envelope. Cytoskeleton
    • Database links
    • Alternative names
      • Apoptosis regulator Bcl X antibody
      • Bcl 2 like 1 antibody
      • Bcl 2 like 1 protein antibody
      • Bcl xL antibody
      • BCL XL/S antibody
      • Bcl xS antibody
      • Bcl2 like1 antibody
      • BCL2-related gene antibody
      • BCL2-related protein, long isoform, included; BCLXL, included antibody
      • BCL2-related protein, short isoform, included; BCLXS, included antibody
      • BCL2L antibody
      • BCL2L1 antibody
      • Bclx antibody
      • DKFZp781P2092 antibody
      • MGC113803 antibody
      • MGC99998 antibody
      see all

    References for Anti-Bcl x antibody (ab93023)

    ab93023 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab93023.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"