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Function
Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane.
Isoform Bcl-X(S) promotes apoptosis.
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Tissue specificity
Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
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Sequence similarities
Belongs to the Bcl-2 family.
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Domain
The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.
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Post-translational
modifications
Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.
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Cellular localization
Mitochondrion membrane. Nucleus membrane. Mitochondrial membranes and perinuclear envelope.
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Information by UniProt
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Database links
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Alternative names
- Apoptosis regulator Bcl X antibody
- Apoptosis regulator Bcl-X antibody
- Apoptosis regulator BclX antibody
- B cell lymphoma 2 like antibody
- B2CL1_HUMAN antibody
- Bcl 2 like 1 protein antibody
- Bcl X antibody
- Bcl xL antibody
- BCL XL/S antibody
- Bcl xS antibody
- Bcl-2-like protein 1 antibody
- Bcl2 Like 1 antibody
- Bcl2 related gene antibody
- Bcl2-L-1 antibody
- BCL2L antibody
- Bcl2l1 antibody
- BCLX antibody
- BclXL antibody
- BclXs antibody
- DKFZp781P2092 antibody
- PPP1R52 antibody
- Protein phosphatase 1 regulatory subunit 52 antibody
see all