FunctionPotent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Isoform Bcl-X(S) promotes apoptosis.
Tissue specificityBcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
Sequence similaritiesBelongs to the Bcl-2 family.
DomainThe BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.
Post-translational modificationsProteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.
Cellular localizationMitochondrion membrane. Nucleus membrane. Mitochondrial membranes and perinuclear envelope.
Protein phosphatase 1 regulatory subunit 52 antibody
Anti-Bcl-XL antibody images
Western blot - Anti-Bcl-XL antibody (ab59349)
All lanes : Anti-Bcl-XL antibody (ab59349) at 1/500 dilution
Lane 1 : Extracts from 293 cells, treated
with UV (30mins) with no immunizing peptide Lane 2 : Extracts from 293 cells, treated
with UV (30mins) with immunizing peptide
Predicted band size : 26 kDa
Anti-Bcl-XL antibody (ab59349)
ab59349, at a 1/50 dilution, staining human Bcl-XL in lung carcinoma, using Immunohistochemistry, Paraffin embedded tissue, in the absence (left image) and presence of the immunizing peptide (right image).
ab59349, at a 1/50 dilution, staining human Bcl2L1 in lung carcinoma, using Immunohistochemistry, Paraffin embedded tissue, in the absence (left image) and presence of the immunizing peptide (right image).
References for Anti-Bcl-XL antibody (ab59349)
has not yet been referenced specifically in any publications.
Publishing research using ab59349? Please let us know so that we can cite the reference in this datasheet.
Concentration of lot no. is
Concentration not available for this lot.
Find concentration of your lot:
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"