Overview

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab8430 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

General Info

  • Alternative names
    • AI132454
    • B cell CLL/lymphoma 10
    • B cell lymphoma/leukemia10
    • B-cell CLL/lymphoma 10
    • B-cell leukemia/lymphoma 10
    • B-cell lymphoma/leukemia 10
    • Bcl 10
    • Bcl-10
    • Bcl10
    • BCL10_HUMAN
    • c E10
    • c-E10
    • C81403
    • CARD containing apoptotic signaling protein
    • CARD containing molecule enhancing NF kappa B
    • CARD containing molecule enhancing NF kB
    • CARD containing molecule enhancing NF-kB
    • CARD containing molecule enhancing NFkB
    • CARD containing proapoptotic protein
    • CARD like apoptotic protein
    • CARD-containing apoptotic signaling protein
    • CARD-containing molecule enhancing NF-kappa-B
    • CARD-containing proapoptotic protein
    • CARD-like apoptotic protein
    • CARMEN
    • Caspase recruiting domain containing protein
    • caspase-recruiting domain-containing protein
    • cCARMEN
    • cE 10
    • cE10
    • CED 3/ICH 1 prodomain homologous E10 like regulator
    • CED-3/ICH-1 prodomain homologous E10-like regulator
    • CED3/ICH1 prodomain homologous E10 like regulator
    • Cellular E10
    • Cellular homolog of vCARMEN
    • Cellular-E10
    • CIPER
    • CLAP
    • hCLAP
    • Mammalian CARD containing adapter molecule E10
    • Mammalian CARD-containing adapter molecule E10
    • mE 10
    • mE10
    • R-RCD1
    see all
  • Function
    Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.
  • Tissue specificity
    Ubiquitous.
  • Involvement in disease
    Note=A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
    Note=Defects in BCL10 are involved in various types of cancer.
  • Sequence similarities
    Contains 1 CARD domain.
  • Post-translational
    modifications
    Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2.
  • Cellular localization
    Cytoplasm > perinuclear region. Membrane raft. Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
  • Information by UniProt

References

ab8430 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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