• Product name
    Anti-Bcl2 alpha antibody
  • Description
    Rabbit polyclonal to Bcl2 alpha
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to N-terminal region of human Bcl2 alpha

  • Positive control
    • human Tonsil



Our Abpromise guarantee covers the use of ab80928 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    IHC-P: 1/200 for 30 min at RT. Perform heat mediated antigen retrieval before commencing with IHC staining protocol, by boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants (alpha and beta) produced by alternate splicing, differ in their C-terminal ends. BCL2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability. It appears to function in a feedback loop system with caspases. BCL2 inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF1). It can form homodimers, and heterodimers with BAX, BAD, BAK and BclX(L). Heterodimerization with BAX requires intact BH1 and BH2 domains, and is necessary for anti-apoptotic activity. Also interacts with APAF1, RAF1, TP53BP2, BBC3, BCL2L1 and BNIPL.
    • Cellular localization
      Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein
    • Database links
    • Alternative names
      • Apoptosis regulator Bcl2 antibody
      • B cell lymphoma protein 2 alpha isoform antibody
      • B cell lymphoma protein 2 antibody
      • B-cell CLL/lymphoma 2 antibody
      • B-cell leukemia/lymphoma 2 antibody
      • Bcl 2 antibody
      • Leukemia /lymphoma, B-cell, 2 antibody
      • Oncogene B-cell leukemia 2 antibody
      see all

    Anti-Bcl2 alpha antibody images

    • Immunohistochemistry analysis of formalin-fixed paraffin-embedded human tonsil tissue with 1/200 ab80928.

    References for Anti-Bcl2 alpha antibody (ab80928)

    ab80928 has not yet been referenced specifically in any publications.

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