Overview

  • Product name
    Anti-Bcl6 antibody, prediluted
    See all Bcl6 primary antibodies
  • Description
    Rabbit polyclonal to Bcl6, prediluted
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Dog, Frog
  • Immunogen

    Synthetic peptide corresponding to Human Bcl6 (internal sequence).
    Database link: P41182

  • Positive control
    • IHC: Human tonsil tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab41846 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: Working dilution: Ready-to-use for 30 min at RT.

    Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.
    • Tissue specificity
      Expressed in germinal center T and B cells and in primary immature dendritic cells.
    • Involvement in disease
      Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.
      Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.
      Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
    • Sequence similarities
      Contains 1 BTB (POZ) domain.
      Contains 6 C2H2-type zinc fingers.
    • Domain
      The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to corepressors BCOR and NCOR2.
    • Post-translational
      modifications
      Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • B cell CLL/lymphoma 6 antibody
      • B cell lymphoma 6 protein antibody
      • B-cell lymphoma 5 protein antibody
      • B-cell lymphoma 6 protein antibody
      • BCL 5 antibody
      • Bcl 6 antibody
      • BCL-5 antibody
      • BCL-6 antibody
      • BCL5 antibody
      • BCL6 antibody
      • BCL6_HUMAN antibody
      • BCL6A antibody
      • cys his2 zinc finger transcription factor antibody
      • LAZ 3 antibody
      • LAZ 3 protein antibody
      • LAZ3 antibody
      • Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3) antibody
      • Lymphoma associated zinc finger gene on chromosome 3 antibody
      • Protein LAZ-3 antibody
      • ZBTB 27 antibody
      • ZBTB27 antibody
      • Zinc finger and BTB domain containing protein 27 antibody
      • Zinc finger and BTB domain-containing protein 27 (ZBTB27) antibody
      • Zinc finger and BTB domain-containing protein 27 antibody
      • Zinc Finger Protein 51 (ZNF51) antibody
      • Zinc finger protein 51 antibody
      • zinc finger transcription factor BCL6S antibody
      • ZNF 51 antibody
      • ZNF51 antibody
      see all

    Images

    • Formalin-fixed, paraffin-embedded human tonsil tissue stained for Bcl6 using ab41846 in immunohistochemical analysis.

    References

    ab41846 has not yet been referenced specifically in any publications.

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    There are currently no Customer reviews or Questions for ab41846.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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