Overview

  • Product nameAnti-BCMO1 antibody
    See all BCMO1 primary antibodies
  • Description
    Rabbit polyclonal to BCMO1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region btween internal sequence amino acids 270-300 of Human BCMO1 (NP_059125.2).

  • Positive control
    • WiDr cell line lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab107418 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 63 kDa.

Target

  • FunctionSymmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed.
  • Tissue specificityHighly expressed in retinal pigment epithelium. Also expressed in kidney, testis, liver, brain, small intestine and colon.
  • PathwayCofactor metabolism; retinol metabolism.
  • Involvement in diseaseDefects in BCMO1 are the cause of autosomal dominant hypercarotenemia and vitamin A deficiency (ADHVAD) [MIM:115300]. Vitamin A is essential for normal embryonic development as well as normal physiological functions in children and adults. Hypercarotenemia is characterized by an excess carotene in the serum, but unlike excess vitamin A, carotene is non-toxic. So far, only a few cases of excess vitamin A have been reported. Individuals were thought to be vitamin A deficient due to an impairment in the conversion of carotenoids to retinal in the intestine.
  • Sequence similaritiesBelongs to the carotenoid oxygenase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • BCDO antibody
    • BCDO1 antibody
    • BCDO1_HUMAN antibody
    • BCMO antibody
    • Bcmo1 antibody
    • BCO antibody
    • BCO1 antibody
    • Beta,beta-carotene 15,15'-monooxygenase antibody
    • beta-carotene 15,15'-monooxygenase 1 antibody
    • Beta-carotene dioxygenase 1 antibody
    • FLJ10730 antibody
    see all

Anti-BCMO1 antibody images

  • Anti-BCMO1 antibody (ab107418) at 1/100 dilution + WiDr cell line lysates at 35 µg

    Predicted band size : 63 kDa

References for Anti-BCMO1 antibody (ab107418)

ab107418 has not yet been referenced specifically in any publications.

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