FunctionTranscriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.
Tissue specificityDetected in testis and prostate. Detected at lower levels in peripheral blood leukocytes and spleen.
Sequence similaritiesBelongs to the BCOR family. Contains 3 ANK repeats.
Post-translational modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.