Anti-BCRP/ABCG2 antibody [5D3] (Biotin) (ab95692)

Overview

  • Product nameAnti-BCRP/ABCG2 antibody [5D3] (Biotin)
    See all BCRP/ABCG2 primary antibodies
  • Description
    Mouse monoclonal [5D3] to BCRP/ABCG2 (Biotin)
  • ConjugationBiotin
  • SpecificityClone 5D3 reacts with the extracellular portion of the Human BCRP/ABCG2 protein.
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    3T3 cells transfected with recombinant Human BCRP/ABCG2.

  • Positive control
    • Peripheral blood leukocytes.

Properties

Applications

Our Abpromise guarantee covers the use of ab95692 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 0.5-1µg for 105-8 cells. A final staining volume of 100µl is recommended.



ab18418-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

Target

  • FunctionXenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
  • Tissue specificityHighly expressed in placenta. Low expression in small intestine, liver and colon.
  • Sequence similaritiesBelongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
    Contains 1 ABC transmembrane type-2 domain.
    Contains 1 ABC transporter domain.
  • Post-translational
    modifications
    Glycosylation-deficient ABCG2 is normally expressed and functional.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ABC transporter antibody
    • ABC15 antibody
    • ABCG 2 antibody
    • ABCG2 antibody
    • ABCG2_HUMAN antibody
    • ABCP antibody
    • ATP binding cassette sub family G (WHITE) member 2 antibody
    • ATP binding cassette transporter G2 antibody
    • ATP-binding cassette sub-family G member 2 antibody
    • BCRP antibody
    • BCRP1 antibody
    • BMDP antibody
    • Breast cancer resistance protein antibody
    • CD338 antibody
    • CDw338 antibody
    • CDw338 antigen antibody
    • EST157481 antibody
    • GOUT1 antibody
    • MGC102821 antibody
    • Mitoxantrone resistance associated protein antibody
    • Mitoxantrone resistance-associated protein antibody
    • MRX antibody
    • Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody
    • MXR antibody
    • MXR1 antibody
    • Placenta specific ATP binding cassette transporter antibody
    • Placenta specific MDR protein antibody
    • Placenta-specific ATP-binding cassette transporter antibody
    • UAQTL1 antibody
    see all

Anti-BCRP/ABCG2 antibody [5D3] (Biotin) images

  • Staining of 3T3 cells transfected with Human BCRP/ABCG2 using 0.5µg of biotin-conjugated mouse IgG2b isotype control (open histogram) or 0.5 µg of ab95692 (filled histogram), followed by streptavidin PE.
    Total viable cells were used for analysis.

References for Anti-BCRP/ABCG2 antibody [5D3] (Biotin) (ab95692)

ab95692 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"