Anti-Beclin 1 (phospho S295) antibody (ab183313)

Overview

  • Product name
    Anti-Beclin 1 (phospho S295) antibody
    See all Beclin 1 primary antibodies
  • Description
    Rabbit polyclonal to Beclin 1 (phospho S295)
  • Specificity
    ab183313 only detects Beclin 1 when phosphorylated at serine 295. Immunolabeling of the Beclin 1 band is eliminated in the Beclin 1 alanine substitution mutant. Additional bands may be observed in non-immunoprecipitated lysates.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Sheep, Chicken, Cow, Dog, Xenopus laevis, Non human primates, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to Human Beclin 1 (phospho S295).
    Database link: Q14457

  • Positive control
    • DDDDK Beclin 1 WT immunoprecipitates expressed in 293T cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab183313 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/250. Predicted molecular weight: 52 kDa.

Target

  • Function
    Plays a central role in autophagy (By similarity). May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Belongs to the beclin family.
  • Cellular localization
    Golgi apparatus > trans-Golgi network membrane. Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • APG6 antibody
    • ATG 6 antibody
    • ATG6 antibody
    • ATG6 autophagy related 6 homolog antibody
    • Bcl-2-interacting protein beclin antibody
    • Beclin 1 (coiled coil moesin like BCL2 interacting protein) antibody
    • Beclin 1 autophagy related antibody
    • Beclin-1 antibody
    • Beclin1 antibody
    • BECN 1 antibody
    • Becn1 antibody
    • BECN1_HUMAN antibody
    • Coiled coil myosin like BCL2 interacting protein antibody
    • Coiled-coil myosin-like BCL2-interacting protein antibody
    • GT197 antibody
    • Protein GT197 antibody
    • VPS 30 antibody
    • VPS30 antibody
    see all

Images

  • All lanes : Anti-Beclin 1 (phospho S295) antibody (ab183313) at 1/250 dilution

    Lane 1 : DDDDK Beclin 1 WT immunoprecipitates expressed in 293T cells
    Lane 2 : DDDDK Beclin 1 alanine-substitution mutant (S295A) immunoprecipitates expressed in 293T cells


    Predicted band size : 52 kDa

References

ab183313 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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