Overview

  • Product nameAnti-Bestrophin 2 antibody
  • Description
    Rabbit polyclonal to Bestrophin 2
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Dog
  • Immunogen

    Synthetic peptide:

    EVHGDFLQRLLPAGAGS

    , corresponding to C terminal amino acids 388 - 404 of Human Bestrophin 2

Properties

Applications

Our Abpromise guarantee covers the use of ab32830 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IP
  • Application notesIP and Pull down assay: 1/200.
    WB: 1/500. Detects a band of approximately 65 kDa (predicted molecular weight: 56 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceThe Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), 1 also known as Best disease. Three more members of the bestrophin family members were cloned and indentified recently, Bestrophin 2, 3 and 4. RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac). Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac and the Bestrophin takes place near the carboxy terminal end of the protein.
    • Cellular localizationCell Membrane
    • Database links
    • Alternative names
      • BEST 2 antibody
      • Best disease Bestrophin antibody
      • BEST2 antibody
      • Bestrophin2 antibody
      • FLJ20132 antibody
      • Vitelliform macular dystrophy 2 homolog antibody
      • Vitelliform macular dystrophy 2 like 1 antibody
      • Vitelliform macular dystrophy 2 like protein 1 antibody
      • Vitelliform macular dystrophy antibody
      • VMD2 antibody
      • VMD2 like gene 1 antibody
      • VMD2L1 antibody
      see all

    References for Anti-Bestrophin 2 antibody (ab32830)

    ab32830 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"