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Products:Neuroscience >> Neurotransmission >> Receptors / Channels >> GPCR >> Adrenergic Receptors
Overview
Product name
Anti-beta 1 Adrenergic Receptor antibody
See all beta 1 Adrenergic Receptor products (5) ...
Description
Rabbit polyclonal to beta 1 Adrenergic Receptor
Tested applications
ELISA, WBmore details
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat
Immunogen
Synthetic peptide derived from internal sequence of human beta 1 Adrenergic Receptor.
Positive control
Extracts from HT-29 cells.
Properties
Form
Liquid
Storage instructions
Store at -20°C. Stable for 12 months at -20°C
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS, 150mM Sodium chloride, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cardiovascular >> Blood >> Blood Pressure regulation
Signal Transduction >> Growth Factors/Hormones >> Adrenalin
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> GPCR
Neuroscience >> Neurotransmission >> Receptors / Channels >> GPCR >> Adrenergic Receptors
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Western blot - beta 1 Adrenergic Receptor antibody (ab64996)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab64996 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
ELISA: 1/20000ELISA: 1/20000
WB: 1/500 - 1/1000.Detects a band of approximately 51 kDa (predicted molecular weight: 51 kDa).
Target
Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.
Domain
The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.
Post-translational
modifications
Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
Cellular localization
Cell membrane. Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression.
Target information above from: UniProt accessionP08588
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- ADR B1 antibody
- ADRB 1 antibody
- ADRB1 antibody
see all
Database links
- Entrez Gene: 153 Human
- Entrez Gene: 11554 Mouse
- Entrez Gene: 24925 Rat
- Omim: 109630 Human
- SwissProt: P08588 Human
- SwissProt: Q5T5Y4 Human
- SwissProt: P34971 Mouse
- SwissProt: P18090 Rat
see all
Anti-beta 1 Adrenergic Receptor antibody images:
Western blot - beta 1 Adrenergic Receptor antibody (ab64996)
All lanes : Anti-beta 1 Adrenergic Receptor antibody (ab64996) at 1/500 dilution
Lane 1 : Extracts from HT-29 cells (5-30 µg of total protein)
Lane 2 : Extracts from HT-29 cells (5-30 µg of total protein) with 5-10µg of the immunising peptide
Predicted band size : 51 kDa
Observed band size : 51 kDa
References for Anti-beta 1 Adrenergic Receptor antibody (ab64996)
ab64996 has not yet been referenced specifically in any publications.
Publishing research using ab64996? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"