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Overview

  • Product nameAnti-beta 1 Spectrin antibody [RBC2/3D5]See all beta 1 Spectrin primary antibodies ...
  • Description
    Mouse monoclonal [RBC2/3D5] to beta 1 Spectrin
  • SpecificityAb49567 recognizes the beta 1 Spectrin in human red blood cells and muscle.
  • Tested applicationsIHC-Fr more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human red blood cell membrane 'ghosts'.

  • Positive controlNormal human striated muscle.

Properties

Applications

Our Abpromise guarantee covers the use of ab49567 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-Fr IHC-Fr: 1/100.

Target

  • FunctionSpectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
  • Involvement in diseaseDefects in SPTB are the cause of elliptocytosis type 3 (EL3) [MIM:182870]. EL3 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
    Defects in SPTB are the cause of spherocytosis type 2 (SPH2) [MIM:182870]; also known as hereditary spherocytosis type 2 (HS2). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH2 is characterized by severe hemolytic anemia. Inheritance is autosomal dominant.
  • Sequence similaritiesBelongs to the spectrin family.
    Contains 2 CH (calponin-homology) domains.
    Contains 17 spectrin repeats.
  • Post-translational
    modifications    The first phosphorylation event occurs on Ser-2114, followed by Ser-2125, Ser-2123, Ser-2128, Ser-2117, and Thr-2110.
  • Cellular localizationCytoplasm > cytoskeleton. Cytoplasm > cell cortex.

    • Target information above from: UniProt accession P11277 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        Alpha Spec antibodyBeta I spectrin antibodyBeta Spec antibody
        Beta spectrin antibodyBeta-I spectrin antibodyEL 2 antibodyEL2 antibodyEL3 antibodyElliptocytosis 2 antibodyElliptocytosis2 antibodyErythrocyte alpha spectrin antibodyerythrocyte antibodyErythroid Alpha Spectrin antibodyHS2 antibodyHSpTB1 antibodyMembrane cytoskeletal protein antibodySpectrin alpha chain erythrocyte antibodySpectrin alpha erythrocytic 1 antibodySpectrin beta antibodySpectrin beta chain antibodySpectrin beta chain erythrocyte antibodySpectrin beta erythrocytic (includes spherocytosis clinical type I) antibodySpectrin beta erythrocytic antibodySPH2 antibodySPT antibodySPTA 1 antibodySPTB 1 antibodySPTB antibodySPTB1 antibodySPTB1_HUMAN antibody
      see all

    References for Anti-beta 1 Spectrin antibody [RBC2/3D5] (ab49567)

    This product has been referenced in:
    • Matsubara S  et al. Changes in the cytoskeletal proteins, sarcoplasmic reticulum, and capillaries in acute relaxant-steroid myopathy (ARSM) in contrast to the corticosteroid myopathy. Acta Neuropathol (Berl) 97:515-9 (1999). Read more (PubMed: 10334490) »

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