Anti-beta 2 Adrenergic Receptor antibody - Aminoterminal end (ab71219)

Overview

  • Product nameAnti-beta 2 Adrenergic Receptor antibody - Aminoterminal endSee all beta 2 Adrenergic Receptor primary antibodies ...
  • Description
    Rabbit polyclonal to beta 2 Adrenergic Receptor - Aminoterminal end
  • Tested applicationsELISA, WB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide selected from the N-terminal region of human BAR2 conjugated to KLH

  • Positive control
    • HL60 cell line lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab71219 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 47 kDa (predicted molecular weight: 47 kDa).

Target

  • FunctionBeta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
  • Post-translational
    modifications
    Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.
    Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK. Phosphorylated upon DNA damage, probably by ATM or ATR.
    Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.
    Ubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation.
  • Cellular localizationCell membrane.
  • Target information above from: UniProt accession P07550 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • ADRB2 antibody
    • ADRB2_HUMAN antibody
    • ADRB2R antibody
    • ADRBR antibody
    • Adrenergic beta 2 receptor surface antibody
    • Adrenoceptor beta 2 surface antibody
    • B2AR antibody
    • BAR antibody
    • beta 2 adrenoceptor antibody
    • Beta 2 adrenoreceptor antibody
    • Beta-2 adrenergic receptor antibody
    • Beta-2 adrenoceptor antibody
    • Beta-2 adrenoreceptor antibody
    • BETA2AR antibody
    • Catecholamine receptor antibody
    • OTTHUMP00000160386 antibody
    see all

Anti-beta 2 Adrenergic Receptor antibody - Aminoterminal end images

  • Anti-beta 2 Adrenergic Receptor antibody - Aminoterminal end (ab71219) at 1/440 dilution + HL60 cell line lysates at 35 µg

    Predicted band size : 47 kDa
    Observed band size : 47 kDa

References for Anti-beta 2 Adrenergic Receptor antibody - Aminoterminal end (ab71219)

ab71219 has not yet been referenced specifically in any publications.

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