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Product name
Anti-beta 2 Microglobulin antibody [D2E9] (HRP)
See all beta 2 Microglobulin products (28) ...
Description
Mouse monoclonal [D2E9] to beta 2 Microglobulin (HRP)
Conjugation
HRP
Tested applications
ELISAmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant full length protein (Human)
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 50% Glycerol, 0.01M PBS, pH 7.0 (+/- 0.1)
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
D2E9
Isotype
IgG1
Light chain type
kappa
Research areas
Cardiovascular >> Blood >> Blood Cell Antigens >> WBC Antigens >> HLA
Cancer >> Tumor biomarkers >> Globulins
Cardiovascular >> Blood >> Serum Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab62864 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
Application notes
ELISA: Use at 1/1000 as detection antibody.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Involvement in disease
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
Sequence similarities
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Post-translational
modifications
Glycation of Ile-21 is observed in long-term hemodialysis patients.
Cellular localization
Secreted. Detected in serum and urine.
Target information above from: UniProt accessionP61769
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- B2M antibody
- B2MG_HUMAN antibody
- Beta 2 microglobulin precursor antibody
see all
Database links
- Entrez Gene: 567 Human
- Omim: 109700 Human
- SwissProt: P61769 Human
- Unigene: 534255 Human
- Unigene: 702947 Human
References for Anti-beta 2 Microglobulin antibody [D2E9] (HRP) (ab62864)
ab62864 has not yet been referenced specifically in any publications.
Publishing research using ab62864? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"