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Anti-beta 2 Microglobulin antibody [F21-21] (Biotin) (ab25160)

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Overview

Product name

Anti-beta 2 Microglobulin antibody [F21-21] (Biotin)
See all beta 2 Microglobulin products (28) ...

Description

Mouse monoclonal [F21-21] to beta 2 Microglobulin (Biotin)

Conjugation

Biotin

Specificity

ab25160 recognises the ß2-microglobulin subunit of MHC Class I molecules

Tested applications

Flow Cyt, IP, WBmore details

Cross reactivity

Reacts with

Chicken, Turkey

Immunogen

The details of the immunogen for this antibody are not available.

Properties

Form

Liquid

Storage instructions

Store at +4°C in the dark.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: PBS

Concentration

Concentration information loading...

Purity

IgG fraction

Clonality

Monoclonal

Clone number

F21-21

Isotype

IgG1

Light chain type

kappa

Research areas

Cardiovascular >> Blood >> Blood Cell Antigens >> WBC Antigens >> HLA
Cancer >> Tumor biomarkers >> Globulins
Cardiovascular >> Blood >> Serum Proteins

Applications

Show applications key

Our Abpromise guarantee covers the use of ab25160 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Flow Cyt

     

  • IP

     

  • WB

     

  • AP

     

Application notes

AP: Use at an assay dependent dilution.
Flow Cyt: Use 1µg for 106 cells.
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 13 kDa.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Involvement in disease

Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.

Sequence similarities

Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Post-translational
modifications

Glycation of Ile-21 is observed in long-term hemodialysis patients.

Cellular localization

Secreted. Detected in serum and urine.

Target information above from: UniProt accessionP61769 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • B2M antibody
  • B2MG_HUMAN antibody
  • Beta 2 microglobulin precursor antibody
  • Beta chain of mhc class 1 proteins antibody
  • Beta-2-microglobulin form pI 5.3 antibody
  • Hdcma22p antibody
see all

Database links

References for Anti-beta 2 Microglobulin antibody [F21-21] (Biotin) (ab25160)

ab25160 has not yet been referenced specifically in any publications.

Publishing research using ab25160? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"