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Anti-beta 2 Microglobulin antibody [F21-21] (FITC) (ab24886)

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Overview

Product name

Anti-beta 2 Microglobulin antibody [F21-21] (FITC)
See all beta 2 Microglobulin products (28) ...

Description

Mouse monoclonal [F21-21] to beta 2 Microglobulin (FITC)

Conjugation

FITC

Specificity

ab24886 recognises Beta 2 Microglobulin of MHC Class I molecules.

Tested applications

WB, Flow Cyt, IPmore details

Cross reactivity

Reacts with

Chicken, Turkey

Immunogen

The details of the immunogen for this antibody are not available.

Positive control

Chicken peripheral blood mononuclear cells.

Properties

Form

Liquid

Storage instructions

Store at +4°C in the dark.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: PBS

Concentration

Concentration information loading...

Purity

IgG fraction

Clonality

Monoclonal

Clone number

F21-21

Isotype

IgG1

Light chain type

kappa

Research areas

Cardiovascular >> Blood >> Blood Cell Antigens >> WBC Antigens >> HLA
Cancer >> Tumor biomarkers >> Globulins
Cardiovascular >> Blood >> Serum Proteins

  • Flow Cytometry / FACS - beta 2 Microglobulin antibody [F21-21] (ab24886)Flow Cytometry / FACS - beta 2 Microglobulin antibody [F21-21] (ab24886) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab24886 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

Flow Cyt: Use 1µg for 106 cells.
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 14 kDa.

NOTE: ab24886 can be used also for immunoaffinity chromatography experiments.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Involvement in disease

Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.

Sequence similarities

Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Post-translational
modifications

Glycation of Ile-21 is observed in long-term hemodialysis patients.

Cellular localization

Secreted. Detected in serum and urine.

Target information above from: UniProt accessionP61769 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • B2M antibody
  • B2MG_HUMAN antibody
  • Beta 2 microglobulin precursor antibody
  • Beta chain of mhc class 1 proteins antibody
  • Beta-2-microglobulin form pI 5.3 antibody
  • Hdcma22p antibody
see all

Database links

Anti-beta 2 Microglobulin antibody [F21-21] (FITC) images:

  Flow Cytometry / FACS - beta 2 Microglobulin antibody [F21-21] (ab24886)

Flow Cytometry / FACS - beta 2 Microglobulin antibody [F21-21] (ab24886)

Chicken peripheral blood mononuclear cells were double stained with ab24886 (1 µg/106 cells) and mouse anti chicken CD3 PE. Small lymphocytes were gated using light scatter criteria and analyzed on a flow cytometer.

References for Anti-beta 2 Microglobulin antibody [F21-21] (FITC) (ab24886)

ab24886 has not yet been referenced specifically in any publications.

Publishing research using ab24886? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"