Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Reassurance, Refunds & Replacements
If your product does not perform as described on this datasheet, we will refund or replace your product...
Read our guarantee »Overview
Product name
Anti-beta 2 Microglobulin antibody [HYB 003-01]
See all beta 2 Microglobulin products (28) ...
Description
Mouse monoclonal [HYB 003-01] to beta 2 Microglobulin
Specificity
This antibody recognises free and MHC class I associated beta 2 microglobulin.
Tested applications
WB, IP, Flow Cytmore details
Cross reactivity
Reacts with caiman. Not yet tested in other species.
Immunogen
Recombinant full length protein (caiman).
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 15mM Sodium Azide
Constituents: 0.5M Sodium chloride, 0.01M PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
HYB 003-01
Myeloma
Sp2/0-Ag14
Isotype
IgG1
Light chain type
kappa
Research areas
Cardiovascular >> Blood >> Blood Cell Antigens >> WBC Antigens >> HLA
Cancer >> Tumor biomarkers >> Globulins
Cardiovascular >> Blood >> Serum Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab17200 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependent dilution. Predicted molecular weight: 13 kDa.
IP: Use at an assay dependent dilution.
Flow Cyt: Use at an assay dependent dilution.
Target
Function
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Involvement in disease
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
Sequence similarities
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Post-translational
modifications
Glycation of Ile-21 is observed in long-term hemodialysis patients.
Cellular localization
Secreted. Detected in serum and urine.
Target information above from: UniProt accessionP61769
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- B2M antibody
- B2MG_HUMAN antibody
- Beta 2 microglobulin precursor antibody
see all
References for Anti-beta 2 Microglobulin antibody [HYB 003-01] (ab17200)
ab17200 has not yet been referenced specifically in any publications.
Publishing research using ab17200? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"