Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Reassurance, Refunds & Replacements
If your product does not perform as described on this datasheet, we will refund or replace your product...
Read our guarantee »Overview
Product name
Anti-beta 2 Microglobulin antibody [HYB332-01]
See all beta 2 Microglobulin products (28) ...
Description
Mouse monoclonal [HYB332-01] to beta 2 Microglobulin
Specificity
This antibody is specific for desLys-58 beta 2 microglobulin.
Tested applications
ELISAmore details
Cross reactivity
Predicted to work with
Human, Chimpanzee, Monkey, Baboon, Gorilla
Immunogen
Synthetic peptide: C-VEHSDLSFS, corresponding to amino acids 49-57 of beta 2 Microglobulin The peptide 'C-VEHSDLSFS' was used for immunizations. The peptide was coupled to carrier protein through the N terminal cysteine amino acid.
C-VEHSDLSFS
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Store at -20ºC.
Storage buffer
Preservative: None
Constituents: 0.5M Sodium chloride, 0.01M PBS, pH 7.4.
Concentration
Concentration information loading...
Purity
Protein A purified
Primary antibody notes
Deslys-58 beta 2 microglobulin is a modified form of beta 2 microglobulin lacking the lysine residue at position 58. This modified form has been shown to be associated with chronic inflammatory conditions and may be implicated in dialysis related amyloidosis.
Clonality
Monoclonal
Clone number
HYB332-01
Myeloma
x63-Ag8.653
Isotype
IgG1
Light chain type
kappa
Research areas
Cardiovascular >> Blood >> Blood Cell Antigens >> WBC Antigens >> HLA
Cancer >> Tumor biomarkers >> Globulins
Cardiovascular >> Blood >> Serum Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab27155 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
ELISA: 1/20.ELISA: 1/20.
Target
Function
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Involvement in disease
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
Sequence similarities
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Post-translational
modifications
Glycation of Ile-21 is observed in long-term hemodialysis patients.
Cellular localization
Secreted. Detected in serum and urine.
Target information above from: UniProt accessionP61769
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- B2M antibody
- B2MG_HUMAN antibody
- Beta 2 microglobulin precursor antibody
see all
Database links
- Entrez Gene: 567 Human
- Omim: 109700 Human
- SwissProt: P61769 Human
- Unigene: 534255 Human
- Unigene: 702947 Human
References for Anti-beta 2 Microglobulin antibody [HYB332-01] (ab27155)
This product has been referenced in:
- Corlin DB et al. Quantification of cleaved beta2-microglobulin in serum from patients undergoing chronic hemodialysis. Clin Chem 51:1177-84 (2005).Read more (PubMed: 15890888) »
- Winchester JF Novel changes in beta2-microglobulin in dialysis patients. Clin Chem 51:1089-90 (2005).Read more (PubMed: 15976094) »
See all 2 publications for this product
Publishing research using ab27155? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"