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Products:Cardiovascular >> Blood >> Serum Proteins
Overview
Product name
Anti-beta 2 Microglobulin antibody
See all beta 2 Microglobulin products (28) ...
Description
Duck polyclonal to beta 2 Microglobulin
Specificity
A single arc was shown while the antibody was reacting with part pure human beta 2 microglobulin by Immunoelectrophoresis. Nothing was shown when the antibody reacted with normal human serum. Similar specific reactions were observed when the antibody was tested by western blot assay.
Tested applications
WB, Immunoelectrophoresis, ELISA, Immunodiffusionmore details
Cross reactivity
Reacts with
Human
Immunogen
Full length native protein (purified) (Human): beta 2 Microglobulin
General notes
ab31137 is an IgY (delta Fc).
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 0.14M Sodium chloride, 10mM PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
ab31137 purity was determined by SDS-PAGE(blue stain), showing that the IgY (deltaFc) constitute was >90% of total protein.
Clonality
Polyclonal
Isotype
IgY
Research areas
Cardiovascular >> Blood >> Blood Cell Antigens >> WBC Antigens >> HLA
Cancer >> Tumor biomarkers >> Globulins
Cardiovascular >> Blood >> Serum Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab31137 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependent dilution. Predicted molecular weight: 14 kDa.
Ie: Use at an assay dependent dilution.
ELISA: Use at an assay dependent dilution.
ID: Use at an assay dependent dilution.
Target
Function
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Involvement in disease
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
Sequence similarities
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Post-translational
modifications
Glycation of Ile-21 is observed in long-term hemodialysis patients.
Cellular localization
Secreted. Detected in serum and urine.
Target information above from: UniProt accessionP61769
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- B2M antibody
- B2MG_HUMAN antibody
- Beta 2 microglobulin precursor antibody
see all
Database links
- Entrez Gene: 567 Human
- Omim: 109700 Human
- SwissProt: P61769 Human
- Unigene: 534255 Human
- Unigene: 702947 Human
References for Anti-beta 2 Microglobulin antibody (ab31137)
ab31137 has not yet been referenced specifically in any publications.
Publishing research using ab31137? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"