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Product Name
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beta 2 Microglobulin antibody
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See all beta 2 Microglobulin antibodies (30)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to beta 2 Microglobulin
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Immunogen
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b 2-Microglobulin [Human Urine]
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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Conjugation, Dot, ELISA, IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
immunoblotting (western or dot blot),
ELISA,
immunoprecipitation,
conjugation
most immunological methods requiring high titer and specificity
A working dilution of 1:50,000 to 1:200,000 of the reconstitution concentration is suggested
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Cellular localization
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Secreted
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Research areas
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Cardiovascular >> Blood >> Blood Cell Antigens >> WBC Antigens >> HLA
Cancer >> Tumor biomarkers >> Globulins
Cardiovascular >> Blood >> Serum Proteins
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Relevance
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Beta 2 Microglobulin non-covalently associates with the 44 kDa alpha chain to form the HLA Class I antigen complex. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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IgG fraction
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Storage buffer
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0.01M Na phosphate, 0.25M NaCl, pH7.6, 0.05% Na azide, 0.01% Thimerisol, 15mg/ml BSA Material safety datasheet (MSDS) for this product:
Sodium Phosphate MSDS
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Purification notes
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This product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum as well as purified and partially purified b 2-Microglobulin [Human Urine].
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Form
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Liquid
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Concentration
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5.000 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Notes
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The antibody reacts with b2-microglobulin isolated from human urine showing a 12.8 kDa band under non-reducing condition of SDS-PAGE.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this beta 2 Microglobulin antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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References for beta 2 Microglobulin antibody (ab6608)
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This product has been used in: (two most recent references)
Pi M et al. GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome. PLoS ONE 3:e3858 (2008). WB; Human. PubMed: 19050760
Yalcin, A and Cetin, M Electrophoretic Separation of Urine Proteins of Healthy Dogs and Dogs with Nephropathy and Detection of Some Urine Proteins of Dogs Using Immunoblotting. Revue Med. Vet. 155:104-112 (2004).
If you publish research using ab6608 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to beta 2 Microglobulin
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