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Anti-beta 2 Microglobulin antibody (ab6608)

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Overview

Product name

Anti-beta 2 Microglobulin antibody
See all beta 2 Microglobulin products (28) ...

Description

Rabbit polyclonal to beta 2 Microglobulin

Tested applications

WB, IP, ELISA, Conjugation, Dot Blot, ICC/IFmore details

Cross reactivity

Reacts with

Human

Immunogen

b 2-Microglobulin [Human Urine]

General notes

The antibody reacts with b2-microglobulin isolated from human urine showing a 12.8 kDa band under non-reducing condition of SDS-PAGE.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

0.01M Na phosphate, 0.25M NaCl, pH7.6, 0.05% Na azide, 0.01% Thimerisol, 15mg/ml BSA

Concentration

Concentration information loading...

Purity

IgG fraction

Purification notes

This product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum as well as purified and partially purified b 2-Microglobulin [Human Urine].

Clonality

Polyclonal

Isotype

IgG

Research areas

Cardiovascular >> Blood >> Blood Cell Antigens >> WBC Antigens >> HLA
Cancer >> Tumor biomarkers >> Globulins
Cardiovascular >> Blood >> Serum Proteins

Applications

Show applications key

Our Abpromise guarantee covers the use of ab6608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    WB

     WB: Use at an assay depe...Read more →

    WB: Use at an assay dependent concentration.

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    IP

     IP: Use at an assay depe...Read more →

    IP: Use at an assay dependent concentration.

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    ELISA

     ELISA: Use at an assay d...Read more →

    ELISA: Use at an assay dependent concentration.

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    Conjugation

     Conjugation: Use at an a...Read more →

    Conjugation: Use at an assay dependent concentration.

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    Dot Blot

     Dot: Use at an assay dep...Read more →

    Dot: Use at an assay dependent concentration.

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    ICC/IF

     ICC/IF: Use at an assay ...Read more →

    ICC/IF: Use at an assay dependent concentration. (PubMed: 20017200)

Target

Function

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Involvement in disease

Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.

Sequence similarities

Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Post-translational
modifications

Glycation of Ile-21 is observed in long-term hemodialysis patients.

Cellular localization

Secreted. Detected in serum and urine.

Target information above from: UniProt accessionP61769 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • B2M antibody
  • B2MG_HUMAN antibody
  • Beta 2 microglobulin precursor antibody
  • Beta chain of mhc class 1 proteins antibody
  • Beta-2-microglobulin form pI 5.3 antibody
  • Hdcma22p antibody
see all

Database links

References for Anti-beta 2 Microglobulin antibody (ab6608)

This product has been referenced in:

  • Kotsiou Eet al. Dimerization of soluble disulfide trap single-chain major histocompatibility complex class I molecules dependent on Peptide binding affinity. Antioxid Redox Signal 15:635-44 (2011). WB; Human.Read more (PubMed: 21050141) »
  • Vecchi Cet al. Huh-7: a human "hemochromatotic" cell line. Hepatology 51:654-9 (2010). ICC/IF; Human.Read more (PubMed: 20017200) »

See all 4 publications for this product

Publishing research using ab6608? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"