Anti-beta 2 Microglobulin antibody - C-terminal (ab80071)

Overview

  • Product nameAnti-beta 2 Microglobulin antibody - C-terminal
    See all beta 2 Microglobulin primary antibodies
  • Description
    Rabbit polyclonal to beta 2 Microglobulin - C-terminal
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide from the C terminal region of Human beta 2 Microglobulin, conjugated to KLH.

  • Positive control
    • Human lung carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab80071 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
IHC-P 1/10 - 1/50.

Target

  • FunctionComponent of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
  • Involvement in diseaseDefects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
    Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
  • Sequence similaritiesBelongs to the beta-2-microglobulin family.
    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Post-translational
    modifications
    Glycation of Ile-21 is observed in long-term hemodialysis patients.
  • Cellular localizationSecreted. Detected in serum and urine.
  • Information by UniProt
  • Database links
  • Alternative names
    • B2M antibody
    • B2MG_HUMAN antibody
    • Beta 2 microglobin antibody
    • Beta 2 microglobulin antibody
    • Beta 2 microglobulin precursor antibody
    • Beta chain of mhc class 1 proteins antibody
    • Beta chain of MHC class I molecules antibody
    • Beta-2-microglobulin form pI 5.3 antibody
    • CDABP0092 antibody
    • Hdcma22p antibody
    see all

Anti-beta 2 Microglobulin antibody - C-terminal images

  • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human lung carcinoma tissue using ab80068 at a 1/10 dilution, with a peroxidase-conjugated secondary antibody, followed by DAB staining.
  • All lanes : Anti-beta 2 Microglobulin antibody - C-terminal (ab80071) at 1/500 dilution

    Lane 1 : Non-transfected 293 cell lysates
    Lane 2 : Beta 2 Microglobulin transfected 293 cell lysates

    Lysates/proteins at 2 µg per lane.

References for Anti-beta 2 Microglobulin antibody - C-terminal (ab80071)

ab80071 has not yet been referenced specifically in any publications.

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Thank you for contacting Abcam. I have been in contact with the labs about our kit and also have some additional details regarding our other Beta-2-Microglobulin products reactivity with porcine.

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