Anti-beta 2 Microglobulin antibody [F21-21] (Biotin) (ab25160)

Overview

  • Product nameAnti-beta 2 Microglobulin antibody [F21-21] (Biotin)
    See all beta 2 Microglobulin primary antibodies
  • Description
    Mouse monoclonal [F21-21] to beta 2 Microglobulin (Biotin)
  • ConjugationBiotin
  • Specificityab25160 recognises the ß2-microglobulin subunit of MHC Class I molecules
  • Tested applicationsSuitable for: Other, Flow Cyt, IP, WBmore details
  • Species reactivity
    Reacts with: Chicken, Turkey
  • Immunogen

    The details of the immunogen for this antibody are not available.

Properties

Applications

Our Abpromise guarantee covers the use of ab25160 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Other
Flow Cyt
IP
WB
AP
  • Application notesAP: Use at an assay dependent dilution.
    Flow Cyt: Use 1µg for 106 cells.
    IP: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 13 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionComponent of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
    • Involvement in diseaseDefects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
      Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
    • Sequence similaritiesBelongs to the beta-2-microglobulin family.
      Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
    • Post-translational
      modifications
      Glycation of Ile-21 is observed in long-term hemodialysis patients.
    • Cellular localizationSecreted. Detected in serum and urine.
    • Information by UniProt
    • Alternative names
      • B2M antibody
      • B2MG_HUMAN antibody
      • Beta 2 microglobin antibody
      • Beta 2 microglobulin antibody
      • Beta 2 microglobulin precursor antibody
      • Beta chain of mhc class 1 proteins antibody
      • Beta chain of MHC class I molecules antibody
      • Beta-2-microglobulin form pI 5.3 antibody
      • CDABP0092 antibody
      • Hdcma22p antibody
      see all

    References for Anti-beta 2 Microglobulin antibody [F21-21] (Biotin) (ab25160)

    ab25160 has not yet been referenced specifically in any publications.

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