Anti-beta 2 Microglobulin antibody [F21-21] (FITC) (ab24886)

Overview

  • Product nameAnti-beta 2 Microglobulin antibody [F21-21] (FITC)
    See all beta 2 Microglobulin primary antibodies
  • Description
    Mouse monoclonal [F21-21] to beta 2 Microglobulin (FITC)
  • ConjugationFITC. Ex: 493nm, Em: 528nm
  • Specificityab24886 recognises Beta 2 Microglobulin of MHC Class I molecules.
  • Tested applicationsSuitable for: WB, Flow Cyt, IPmore details
  • Species reactivity
    Reacts with: Chicken, Turkey
  • Immunogen

    The details of the immunogen for this antibody are not available.

  • Positive control
    • Chicken peripheral blood mononuclear cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab24886 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 14 kDa.
Flow Cyt Use 1µg for 106 cells. ab106163-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.
AP Use at an assay dependent concentration.

ab24886 can be used also for immunoaffinity chromatography experiments.

Target

  • FunctionComponent of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
  • Involvement in diseaseDefects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
    Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
  • Sequence similaritiesBelongs to the beta-2-microglobulin family.
    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Post-translational
    modifications
    Glycation of Ile-21 is observed in long-term hemodialysis patients.
  • Cellular localizationSecreted. Detected in serum and urine.
  • Information by UniProt
  • Alternative names
    • B2M antibody
    • B2MG_HUMAN antibody
    • Beta 2 microglobin antibody
    • Beta 2 microglobulin antibody
    • Beta 2 microglobulin precursor antibody
    • Beta chain of mhc class 1 proteins antibody
    • Beta chain of MHC class I molecules antibody
    • Beta-2-microglobulin form pI 5.3 antibody
    • CDABP0092 antibody
    • Hdcma22p antibody
    see all

Anti-beta 2 Microglobulin antibody [F21-21] (FITC) images

  • Chicken peripheral blood mononuclear cells were double stained with ab24886 (1 µg/106 cells) and mouse anti chicken CD3 PE. Small lymphocytes were gated using light scatter criteria and analyzed on a flow cytometer.

References for Anti-beta 2 Microglobulin antibody [F21-21] (FITC) (ab24886)

ab24886 has not yet been referenced specifically in any publications.

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