Anti-beta 3 Adrenergic Receptor antibody (ab77588)
Key features and details
- Goat polyclonal to beta 3 Adrenergic Receptor
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-beta 3 Adrenergic Receptor antibody
See all beta 3 Adrenergic Receptor primary antibodies -
Description
Goat polyclonal to beta 3 Adrenergic Receptor -
Host species
Goat -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Chimpanzee -
Immunogen
Synthetic peptide:
PHENSSLAPWPD-C
, corresponding to N terminal amino acids 5-16 of human beta 3 Adrenergic Receptor (NP_000016.1) -
Positive control
- Human brain (cerebellum, cerebral cortex, frontal cortex) lysates.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 0.5% Tris buffered saline -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
ab77588 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab77588 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Notes |
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WB: Use at a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 45 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. -
Tissue specificity
Expressed mainly in adipose tissues. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 464113 Chimpanzee
- Entrez Gene: 155 Human
- Omim: 109691 Human
- SwissProt: P13945 Human
- Unigene: 2549 Human
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Alternative names
- ADR B3 antibody
- ADRB 3 antibody
- ADRB3 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab77588 has been referenced in 2 publications.
- Pasha A et al. ß3-Adrenoreceptor Activity Limits Apigenin Efficacy in Ewing Sarcoma Cells: A Dual Approach to Prevent Cell Survival. Int J Mol Sci 20:N/A (2019). PubMed: 31052299
- O'Leary AP et al. Beta-Adrenoceptor Activation Reduces Both Dermal Microvascular Endothelial Cell Migration Via a cAMP-Dependent Mechanism and Wound Angiogenesis. J Cell Physiol N/A:N/A (2014). WB ; Human . PubMed: 24986762