Mouse, Rat, Sheep, Rabbit, Chicken, Guinea pig, Hamster, Cow, Cat, Dog, Human, Pig, Carp, Monkey Predicted to work with:
a wide range of other speciesDoes not react with:
Fruit fly (Drosophila melanogaster), Dictyostelium discoideum
Synthetic N terminal peptide:
conjugated to KLH, corresponding 100% to a sequence from: Xenopus borealis (Kenyan clawed frog), Lytechinus pictus (Painted sea urchin) and Engystomops pustulosus (Tungara frog).
FunctionActins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Involvement in diseaseDefects in ACTB are a cause of dystonia juvenile-onset (DYTJ) [MIM:607371]. DYTJ is a form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYTJ patients manifest progressive, generalized, dopa-unresponsive dystonia, developmental malformations and sensory hearing loss.
References for Anti-beta Actin antibody [AC-15] (HRP) (ab49900)
This product has been referenced in:
Lee JK et al. Age and the means of bypassing stasis influence the intrinsic subtype of immortalized human mammary epithelial cells. Front Cell Dev Biol3:13 (2015).
Read more (PubMed: 25815289) »
DeHart CJ et al. Extensive post-translational modification of active and inactivated forms of endogenous p53. Mol Cell Proteomics13:1-17 (2014).
Read more (PubMed: 24056736) »