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Product Name
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beta Amyloid 1-40 antibody [BAM-10]
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See all beta Amyloid 1-40 antibodies (9)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [BAM-10] to beta Amyloid 1-40
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Immunogen
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Synthetic peptide conjugated to KLH, corresponding to amino acids 1-40 of beta Amyloid.
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Reacts with
(species key)
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Hu
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Specificity
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This antibody reacts with beta amyloid protein. This antibody stains Amyloid plaques within the cortex, and Amyloid deposits in blood vessels. Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, amyloidosis and in Gram-Parkinson dementia complex. The presence to a large number of neuritic plaques (senile) and neurofibrillary tangles in the cerebral cortex is used a pathological marker for a disease state and presents the major criterion for the diagnosis of Alzheimer’s disease at autopsy.
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Tested applications
(see key)
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IHC-Fr, IHC-P
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: Use at an assay dependent dilution.
IHC-Fr: Use at an assay dependent dilution.
We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user. Suitable for formalin/paraffin tissues.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Brain.
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Cellular localization
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Cell Membrane (single-pass type I membrane protein), Golgi Apparatus and Secreted
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Research areas
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Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Amyloid
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Relevance
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The cerebral and vascular plaques associated with Alzheimer's disease (AD) are mainly composed of amyloid beta peptides (Ab). Ab is derived from cleavage of the amyloid precursor protein (APP) and varies in length from 39 to 43 amino acids. Ab [1-40], Ab [1-42], and Ab [1-43] peptides result from cleavage of APP after residues 40, 42, and 43, respectively. The cleavage takes place by gamma secretase during the last APP processing step. Ab [1-40], [1-42] and [1-43] peptides are major constituents of the plaques and tangles that occur in AD. Ab antibodies and peptides have been developed as tools for elucidating the biology of AD.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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BAM-10
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Isotype
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IgG1
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Purity
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Ascites
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Storage buffer
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Preservative: 0.05% Sodium Azide
Constituents: 1% BSA, Ascites Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Store at +4°C.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this beta Amyloid 1-40 antibody [BAM-10] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to beta Amyloid 1-40
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beta Amyloid 1-40 antibody [BAM-10] - more information
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