beta Amyloid 1-40 antibody [BDI350] (ab20068)

Product Name 

beta Amyloid 1-40 antibody [BDI350]

Product type 

Primary antibodies

Description 

Mouse monoclonal [BDI350] to beta Amyloid 1-40

Immunogen 

Peptide conjugated to KLH (C terminal).

Reacts with 
(species key)

Hu

Specificity 

Interacts with the C terminus of beta Amyloid 1-40. Does not cross react with beta Amyloid 1-42.

Tested applications 
(see key)

ELISA, ICC, IHC-P, WB

Abreviews 

Customer reviews (see key)

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Application notes 
(see key)

Recommended dilutions
ELISA: Use at a concentration of 0.1 µg/ml.
ICC: Use at a concentration of 1 - 10 µg/ml.
WB: Use at a concentration of 1 µg/ml for AP / BCIP/ NBT(MTT) detection and 0.1 µg/ml for HRPO / ECL detection. Predicted molecular weight: 87 kDa.
Dilution optimised using Chromogenic detection.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Cell Membrane (single-pass type I membrane protein), Golgi Apparatus and Secreted

Research areas 

Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Amyloid

Relevance 

The cerebral and vascular plaques associated with Alzheimer's disease (AD) are mainly composed of amyloid beta peptides (Ab). Ab is derived from cleavage of the amyloid precursor protein (APP) and varies in length from 39 to 43 amino acids. Ab [1-40], Ab [1-42], and Ab [1-43] peptides result from cleavage of APP after residues 40, 42, and 43, respectively. The cleavage takes place by gamma secretase during the last APP processing step. Ab [1-40], [1-42] and [1-43] peptides are major constituents of the plaques and tangles that occur in AD. Ab antibodies and peptides have been developed as tools for elucidating the biology of AD.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

BDI350

Isotype 

IgG1

Purity 

Tissue culture supernatant

Storage buffer 

Preservative: 0.09% Sodium Azide
Constituents: PBS, Polyethylene glycol, Sucrose

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Purification notes 

Thiophilic adsorption and size exclusion chromatography.

Form 

Liquid

Concentration 

0.100 mg/ml

Storage instructions 

Store at +4°C.

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References for beta Amyloid 1-40 antibody [BDI350] (ab20068)

  This product has been used in:

Lee JH et al. Electrical detection of beta-amyloid (1-40) using scanning tunneling microscopy. Ultramicroscopy 109:923-8 (2009). PubMed: 19345496

If you publish research using ab20068 please let us know so that we can cite the reference on this datasheet.

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