Amyloidogenic peptide. Occupies the extracellular region of amyloid precursor protein, that can form an α-helical or oligomeric beta-sheet. Responsible for amyloid conformational variability. Conformational change induced by N-terminal metal binding. Cytotoxic in vitro.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 1 mg/ml
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Alvarez XA et al. Intrahippocampal injections of the beta-amyloid 1-28 fragment induces behavioral deficits in rats. Methods Find Exp Clin Pharmacol19:471-9 (1997).
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Maneiro E et al. An experimental model to study the cytotoxic effects induced by beta-amyloid, histamine, LPS and serum from Alzheimer patients on cultured rat endothelial cells. Methods Find Exp Clin Pharmacol19:5-12 (0).
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