Highly toxic, amyloidogenic amyloid beta (1-43) peptide fragment
Amyloid β peptide fragment. Highly toxic, showing higher neurotoxicity compared to Aβ40 and Aβ42 (ab120479 / ab120301). Aggregates and is potently amyloidogenic in vivo. Induces synaptic dysfunction and impairs memory.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 1 mg/ml
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Jarrett JT et al. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry32:4693-7 (1993).
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Hilbich C et al. Human and rodent sequence analogs of Alzheimer's amyloid beta A4 share similar properties and can be solubilized in buffers of pH 7.4. Eur J Biochem201:61-9 (1991).
Read more (PubMed: 1915378) »